Protective Effects of MK‐801 on Apoptosis in Immature Rats With Traumatic Brain Injury

This study demonstrated that treatment with MK-801 significantly reduces apoptosis in the hippocampus by downregulating key pro-apoptotic markers, including BAX, cytochrome c and caspase-3. These findings suggest that MK-801 exerts a neuroprotective effect by interfering with the intrinsic apoptotic pathway following TBI.

Authors

Oya Sayın (ORCID: https://orcid.org/0000-0003-0879-9091)
Ayşe Çiğel (ORCID: https://orcid.org/0000-0002-9512-6997)
Seren Gülşen Gürgen (ORCID: https://orcid.org/0000-0002-5514-1404)
Başar Koç
Ataç Sönmez (ORCID: https://orcid.org/0000-0002-6897-9804)

Institutions

Izmir University (TR)
Manisa Celal Bayar University (TR)
Dokuz Eylül University (TR)

Publication Details

Journal: International Journal of Developmental Neuroscience
Published: 2025-08-01
DOI: https://doi.org/10.1002/jdn.70043
Primary Topic: Anesthesia and Neurotoxicity Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Protective Effects of MK‐801 on Apoptosis in Immature Rats With Traumatic Brain Injury

Oya Sayın, Ayşe Çiğel, Seren Gülşen Gürgen, Başar Koç et al.

Aug 1, 2025

International Journal of Developmental Neuroscience

Anesthesia and Neurotoxicity Research

article

Protective Effects of MK‐801 on Apoptosis in Immature Rats With Traumatic Brain Injury

Oya Sayın, Ayşe Çiğel, Seren Gülşen Gürgen, Başar Koç, Ataç Sönmez

August 1, 2025article en

Abstract

This study demonstrated that treatment with MK-801 significantly reduces apoptosis in the hippocampus by downregulating key pro-apoptotic markers, including BAX, cytochrome c and caspase-3. These findings suggest that MK-801 exerts a neuroprotective effect by interfering with the intrinsic apoptotic pathway following TBI.

International Journal of Developmental NeuroscienceVol. 85(5)

Izmir University (TR), Manisa Celal Bayar University (TR), Dokuz Eylül University (TR)

Good health and well-being

Openalex Percentile: Top 77%

Anesthesia and Neurotoxicity Research

DOI Source OpenAlex

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Protective Effects of MK‐801 on Apoptosis in Immature Rats With Traumatic Brain Injury — Oya Sayın, Ayşe Çiğel, et al. · International Journal of Developmental Neuroscience (2025) | TGRS Research Map | TGRS