Evaluation of Bak and Bcl-Xl gene expression among pediatric patients with acute primary immune thrombocytopenia
Pediatric patients with acute primary ITP exhibited a heightened proapoptotic state, as indicated by an increased Bak expression and Bak/Bcl-Xl expression ratio, as well as a reduced Bcl-Xl expression. IVIG therapy appears to mitigate this pro-apoptotic effect, suggesting its ability to restore platelet homeostasis.
Authors
- MahmoudA El-Hawy
- Ahmed Badawy (ORCID: https://orcid.org/0000-0002-4966-3839)
- Iman A. Ahmedy (ORCID: https://orcid.org/0000-0003-0816-3050)
- Sonja Kandel (ORCID: https://orcid.org/0000-0002-5085-3373)
- Sally Mohamed El‐Hefnawy
- Hanan Hassan El‐sheity
- Dina Fouad Sief El-Nasr Zidan
Institutions
- Menoufia University (EG)
Publication Details
- Journal
- Clinical and Experimental Pediatrics
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3345/cep.2025.00997
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00