Inflammatory Markers in Gastric Fluids Differentiate Patients With Eosinophilic Gastritis: Search for a Disease Screener

We successfully measured inflammatory markers in gastric secretions. Th2-mediated cytokines were elevated in gastric secretions in EoG, differentiating them from EoE and expanding our understanding of inflammation in EoG. Notably, our results are the first to implicate matrix metalloproteinases in the EoG inflammatory process. Importantly, we found that gastric secretions can discern patients with active gastric eosinophilia involvement. Modeling identified 9 markers that predicted EoG with an area under the curve of 0.86. With further validation, gastric fluids could be used as an easy test to screen EoG by identify patients who would benefit from histopathologic enumeration of eosinophils on biopsies.