The focal index: a quantitative approach to morphological sub-phenotyping of COVID-19 patients with acute respiratory distress syndrome: a pilot study
The analysis suggested diffuse lung injury includes a spectrum of focality rather than a binary classification. The focal index provides an objective method to quantify the focality of lung injury in ARDS. Further studies are needed to validate the focal index across diverse ARDS aetiologies and establish its clinical application threshold for guiding personalised ventilation strategies.
Authors
- Rafael Kawati (ORCID: https://orcid.org/0009-0007-1322-5777)
- Gaetano Perchiazzi (ORCID: https://orcid.org/0000-0001-6834-6399)
- Miklós Lipcsey (ORCID: https://orcid.org/0000-0002-1976-4129)
- Lucian Covaciu
- Kristin Jona Bjarnadottir (ORCID: https://orcid.org/0009-0007-2943-6405)
- M Pellégrini (ORCID: https://orcid.org/0009-0007-1483-2763)
- Magnus von Seth (ORCID: https://orcid.org/0000-0002-2039-5017)
- Martin Tovedal
Institutions
- Uppsala University Hospital (SE)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1186/s40635-025-00794-0
- Citations
- 4
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- Vetenskapsrådet
- Akademiska Sjukhuset
- Uppsala Universitet