Investigation and optimization of tumor-treating fields technique for breast cancer treatment: a simulation study

Tumor-treating fields (TTFields) use alternating electric fields (1-3 V/cm, 100-300 kHz) to disrupt tumor cell division. This study explored TTFields for breast cancer using a COMSOL-based model of a breast with irregular tumors in various glandular positions and volumes. Multiple electrode configurations were analyzed. Skin temperature over time was evaluated using the bioheat equation. Results showed that applying ±20 V with a 12-electrode setup delivered effective tumor targeting while maintaining safe skin temperatures. This finite-element analysis highlights TTFields' potential for breast cancer therapy and provides a foundation for optimizing treatment parameters in future clinical applications.