General mental ability (Spearman's g) in Juvenile Myoclonic Epilepsy
General mental ability, or g, is an important aspect of a person's cognitive ability. We found g to be lower in JME patients compared to controls and to be linked to features of their family, neighborhood, and brain. The protective effects of g could be shown by dividing participants into high and low g groups. High g participants exhibited few differences compared to controls, while, in contrast, low g participants showed poorer cognition, school performance, came from deprived neighborhoods, and had more problematic family features. Importantly, lower g was linked to measures of the brain, suggesting slowed neurodevelopment.
Authors
- Nagesh Adluru (ORCID: https://orcid.org/0000-0001-8330-1770)
- Bruce P. Hermann (ORCID: https://orcid.org/0000-0003-0133-4427)
- Anusha Adluru (ORCID: https://orcid.org/0009-0008-6455-9299)
- Aaron F. Struck (ORCID: https://orcid.org/0000-0002-9103-1798)
- Dace N. Almane (ORCID: https://orcid.org/0000-0001-7889-5922)
- Camille Garcia‐Ramos
- Vivek Prabhakaran (ORCID: https://orcid.org/0000-0002-1974-3125)
- Veena A. Nair (ORCID: https://orcid.org/0000-0002-5666-3239)
- Jana E. Jones (ORCID: https://orcid.org/0000-0003-1723-0163)
Institutions
- University of Wisconsin–Madison (US)
- William S. Middleton Memorial Veterans Hospital (US)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1002/epi4.70111
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development