CXCR4-Mediated Chemokine Signaling Orchestrates the Progression of Conjunctival Melanocytic Lesions
CXCR4-mediated chemokine signaling pathway is significantly upregulated in CoM. Pharmacological blockade of CXCR4 with AMD3100 exerts cytotoxic effects on CoM cells through inhibition of PI3K/Akt and MEK/ERK pathways, indicating CXCR4 as a promising translational target that warrants further investigation and clinical validation.
Authors
- Mingfeng Qiu (ORCID: https://orcid.org/0000-0001-5735-3518)
- Ziyue Huang (ORCID: https://orcid.org/0000-0002-1096-6365)
- Yamin Rao (ORCID: https://orcid.org/0000-0002-2131-7213)
- Tianyu Zhu (ORCID: https://orcid.org/0000-0002-4781-7398)
- Renbing Jia (ORCID: https://orcid.org/0000-0001-6642-7451)
- Shiqiong Xu (ORCID: https://orcid.org/0000-0003-3811-6482)
- Jie Chen (ORCID: https://orcid.org/0009-0003-2727-0289)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Eye Disease Prevention & Treatment Center (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1167/iovs.66.11.23
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University