The role of diet in moderating the relationship between symptoms of depression and brain amyloid load
The Dietary Approaches to Stop Hypertension (DASH) diet moderates the links among depression, anxiety, and brain amyloid load. Higher symptoms were linked to greater amyloid load in those with low DASH adherence. This effect was observed for anxiety symptoms in apolipoprotein E ε4 allele carriers. Mediterranean and Western diets did not moderate these relationships. Findings support genotype-specific dietary interventions for brain and mental health.
Authors
- Vincent Doré (ORCID: https://orcid.org/0000-0002-8051-0558)
- Hamid R. Sohrabi (ORCID: https://orcid.org/0000-0001-8017-8682)
- Kevin Taddei (ORCID: https://orcid.org/0000-0002-8106-7957)
- Colin L. Masters (ORCID: https://orcid.org/0000-0003-3072-7940)
- Samantha L. Gardener (ORCID: https://orcid.org/0000-0002-1933-5260)
- Stephanie R. Rainey‐Smith (ORCID: https://orcid.org/0000-0001-7328-9624)
- Ralph N. Martins (ORCID: https://orcid.org/0000-0002-4828-9363)
- Warnakulasuriya Mary Ann Dipika Binosha Fernando (ORCID: https://orcid.org/0000-0002-8364-7808)
- Hilal Salim Said Al Shamsi
- Christopher C. Rowe
Institutions
- Edith Cowan University (AU)
- The University of Melbourne (AU)
- Murdoch University (AU)
- The University of Western Australia (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Australian e-Health Research Centre (AU)
- Australian Alzheimer’s Research Foundation (AU)
- Austin Health (AU)
- Macquarie University (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70560
- Citations
- 5
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- Alzheimer's Association
- Commonwealth Scientific and Industrial Research Organisation
- University of Melbourne
- Edith Cowan University
- National Health and Medical Research Council