One-step synthesis of 2-arylindoles from indolines <i>via</i> Pd-catalyzed oxidative dehydrogenation and C2-selective arylation
We report an efficient synthetic approach to 2-arylindoles from indolines <i>via</i> a one-step process involving Pd-catalyzed oxidative dehydrogenation and a sequential C2-regioselective Heck-type reaction. The mild reaction conditions, which utilize O<sub>2</sub> as the sole oxidant, show a broad substrate scope and good functional group compatibility.
Authors
- Nam‐Jung Kim (ORCID: https://orcid.org/0000-0003-3991-5470)
- Jonggu Jeon (ORCID: https://orcid.org/0000-0002-4301-7529)
- Jeong-Won Shin (ORCID: https://orcid.org/0009-0009-9981-4197)
- Jaehoon Sim (ORCID: https://orcid.org/0000-0001-7981-9892)
- Yo‐Sep Yang
- Hyuck-Jae Won
- H-S Hwang
- Ju Hee Kim (ORCID: https://orcid.org/0000-0002-4945-0753)
- Jiyeon Yoo
- Jun Hwi Bak
Institutions
- Kyung Hee Cyber University (KR)
- Kyung Hee University (KR)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra04628a
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Research Foundation
- Kyung Hee University
- National Research Foundation of Korea