Identification of potential molecular targets of luteolin in the treatment of hepatocellular carcinoma based on network pharmacology and transcriptome sequencing technology
LLUT suppresses HCC progression by inhibiting proliferation, regulating cell cycle and apoptosis, and blocking invasion and migration. Its therapeutic mechanisms likely involve targeting MMP9 and modulating the HIF-1α signaling pathway.
Authors
- Hongwei Cui (ORCID: https://orcid.org/0000-0002-5352-548X)
- Yang Xiong (ORCID: https://orcid.org/0000-0002-9508-1987)
- Yunqi Han
- Huijun Wu (ORCID: https://orcid.org/0000-0001-5586-1607)
- Wei Lv (ORCID: https://orcid.org/0000-0002-4913-9041)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-9826-1564)
- Xinyuan Tian (ORCID: https://orcid.org/0009-0004-8677-6586)
- Yunfeng Xiao
Institutions
- Second Military Medical University (CN)
- Second Affiliated Hospital of Inner Mongolia Medical University (CN)
- Inner Mongolia People's Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- Fourth Hospital of Inner Mongolia (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1007/s12672-025-03144-4
- Citations
- 2
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Inner Mongolia Medical University
- Natural Science Foundation of Inner Mongolia