Integrating single-cell RNA sequencing and spatial transcriptomics reveals the therapeutic effect of nitazoxanide in head and neck squamous cell carcinoma
Our findings established that Nitazoxanide has the potential to play a role in the treatment of HNSCC. We suggested that Nitazoxanide acts on NKX2-3, PINK1, BIRC5 and CDKN2A to inhibit the development of HNSCC through regulating autophagy, and it is a promising candidate drug for HNSCC.
Authors
- Liqi Chen (ORCID: https://orcid.org/0000-0002-6543-3419)
- Mang Xiao (ORCID: https://orcid.org/0000-0002-7131-6251)
- Jing Ye (ORCID: https://orcid.org/0000-0002-9471-3321)
- Zhongxu Xu
- Xiaohua Jiang (ORCID: https://orcid.org/0009-0006-0049-3548)
- Huey‐Fang Sun (ORCID: https://orcid.org/0000-0002-5671-0699)
- Ziwei Guo
Institutions
- Wenzhou Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1007/s12672-025-03372-8
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94