Intraoperative Cerebrospinal Fluid Leaks During Endoscopic Endonasal Tumor Resection are Associated With Higher Emesis Rates and Greater Opioid Use in the Acute Postoperative Period
Intraoperative CSF leaks serve as an exacerbating factor for postoperative emesis, both of which are associated with increased opioid use and patient length of stay. After implementing an opioid-sparing protocol, emesis rates were lower; however, this did not translate to reduced postoperative CSF rhinorrhea. Future research is necessary to better characterize the causal relationship between these perioperative complications, including the role of opioid minimization to prevent postoperative CSF leaks.
Authors
- Jacob Ruzevick
- John D. Carmichael (ORCID: https://orcid.org/0000-0002-3194-9249)
- Ilaria Bove (ORCID: https://orcid.org/0000-0003-3909-7420)
- Joshua Lopez
- David J. Coté (ORCID: https://orcid.org/0000-0001-5419-1517)
- Dhiraj J. Pangal (ORCID: https://orcid.org/0000-0001-7391-9825)
- Elisabeth H. Ference (ORCID: https://orcid.org/0000-0002-4177-6716)
- Bozena Wrobel (ORCID: https://orcid.org/0000-0002-7323-1702)
- Ishan Shah (ORCID: https://orcid.org/0009-0008-0910-5956)
- Robert G. Briggs (ORCID: https://orcid.org/0000-0001-9329-4471)
- Justin Chan (ORCID: https://orcid.org/0000-0002-2164-4724)
- Racheal Peterson
- Gabriel Zada (ORCID: https://orcid.org/0000-0001-5821-902X)
- David Gómez (ORCID: https://orcid.org/0000-0003-3612-661X)
- Sweta Bhagavatula
Institutions
- University of Southern California (US)
Publication Details
- Journal
- Operative Neurosurgery
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1227/ons.0000000000001739
- Citations
- 1
- Primary Topic
- Head and Neck Surgical Oncology
- Type
- article
- Field-Weighted Citation Impact
- 2.01