Genetic Loss of RORα Impairs Visual Function With Rod Bipolar Cell Degeneration In Mice
Our findings demonstrate that RORα is indispensable for the structural and functional maintenance of rod bipolar cells and could pose as a potential therapeutic target for mitigating bipolar cell deficits in retinal degenerative diseases.
Authors
- Laura A. Solt
- James D. Akula (ORCID: https://orcid.org/0000-0001-8049-1812)
- Chi‐Hsiu Liu (ORCID: https://orcid.org/0000-0002-8830-7407)
- Kiran Bora (ORCID: https://orcid.org/0000-0002-6105-5211)
- Madeline C. Pavlovich
- Meenakshi Maurya (ORCID: https://orcid.org/0000-0002-2632-4789)
- Jing Chen (ORCID: https://orcid.org/0000-0002-9183-8698)
- Ye Sun (ORCID: https://orcid.org/0000-0002-7674-9056)
- Neetu Kushwah (ORCID: https://orcid.org/0000-0003-4032-8484)
- Zhongjie Fu
Institutions
- Scripps Research Institute (US)
- Boston Children's Hospital (US)
- Harvard University (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1167/iovs.66.11.20
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Massachusetts Lions Eye Research Fund
- Ögonfonden
- National Institutes of Health
- National Eye Institute