Antibiotic Use and the Risk of Hospital-Onset <i>Clostridioides Difficile</i> Infection
In this cohort study, carriers of C difficile had a substantially higher baseline hazard for hospital-onset CDI. Antibiotic exposure was associated with an increased hazard among noncarriers but was not significantly associated with additional hazard among carriers. These findings suggest that while antibiotic stewardship may reduce CDI risk in noncarriers, additional strategies may be needed for carriers given their elevated baseline risk.
Authors
- Mayan Gilboa (ORCID: https://orcid.org/0000-0003-1754-7750)
- Dafna Yahav (ORCID: https://orcid.org/0000-0003-3181-9791)
- Tal Zilberman‐Daniels
- Eyal Meltzer (ORCID: https://orcid.org/0000-0001-5754-6221)
- Gili Regev‐Yochay (ORCID: https://orcid.org/0000-0001-7163-4607)
- Amitai Segev (ORCID: https://orcid.org/0000-0002-6653-7543)
- Noam Barda (ORCID: https://orcid.org/0000-0002-3400-235X)
- Ido Cohen (ORCID: https://orcid.org/0000-0003-4528-8194)
- Yovel Peretz
- Sharon Amit (ORCID: https://orcid.org/0000-0002-0867-1824)
Institutions
- Ben-Gurion University of the Negev (IL)
- Tel Aviv University (IL)
- Sheba Medical Center (IL)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.25252
- Citations
- 5
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 6.98