Evaluation of the drug-drug interaction between low-dose methotrexate and short-term use of non-steroidal anti-inflammatory drugs

In our opinion, no additional safety monitoring is required during short-term NSAID use in patients using LD-MTX in the absence of risk factors. In the presence of risk factors, i.e. renal insufficiency, dosage MTX > 20 mg/week, diabetes mellitus, dehydration, and use of acetylsalicylic acid in analgesic dose, DDI management should be individualized.

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Journal
Expert Opinion on Drug Metabolism & Toxicology
Published
2025-08-08
DOI
https://doi.org/10.1080/17425255.2025.2546127
Primary Topic
Pregnancy and Medication Impact
Type
article
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article

Evaluation of the drug-drug interaction between low-dose methotrexate and short-term use of non-steroidal anti-inflammatory drugs

Merel van Nuland, Tom Jacobs, Madelon Butterhoff, Paul D van der Linden et al.
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Expert Opinion on Drug Metabolism & Toxicology
Pregnancy and Medication Impact
article

Evaluation of the drug-drug interaction between low-dose methotrexate and short-term use of non-steroidal anti-inflammatory drugs

Merel van Nuland, Tom Jacobs, Madelon Butterhoff, Paul D van der Linden, Manon G. den Uil
article en

Abstract

In our opinion, no additional safety monitoring is required during short-term NSAID use in patients using LD-MTX in the absence of risk factors. In the presence of risk factors, i.e. renal insufficiency, dosage MTX > 20 mg/week, diabetes mellitus, dehydration, and use of acetylsalicylic acid in analgesic dose, DDI management should be individualized.

Expert Opinion on Drug Metabolism & ToxicologyVol. 21(9)
Radboud University Nijmegen (NL), Utrecht University (NL), University Medical Center (US), Radboud University Medical Center (NL), University Medical Center Utrecht (NL), Tergooi (NL)
Good health and well-being
Openalex Percentile: Top 72%
Pregnancy and Medication Impact
DOIOpen Access PDFOpenAlex
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Evaluation of the drug-drug interaction between low-dose methotrexate and short-term use of non-steroidal anti-inflammatory drugs — Merel van Nuland, Tom Jacobs, et al. · Expert Opinion on Drug Metabolism & Toxicology (2025) | TGRS Research Map | TGRS