Redefining AT1 Receptor PET Imaging: Introducing the Radiotracer [ <sup>18</sup> F]DR29
These results support [<sup>18</sup>F]DR29 as a promising tool for the noninvasive evaluation of renal AT1R expression in healthy and diseased states. The findings lay the groundwork for clinical translation, offering potential applications in diagnosing and managing kidney-related diseases, including hypertension and other conditions involving AT1R dysregulation.
Authors
- Naoko Nose (ORCID: https://orcid.org/0000-0001-6302-1966)
- Takanori Sasaki (ORCID: https://orcid.org/0000-0002-0821-827X)
- Rudolf Alexander Werner (ORCID: https://orcid.org/0000-0003-3372-6046)
- Paula-Anahi Arias-Loza (ORCID: https://orcid.org/0000-0003-4048-4719)
- Takahiro Higuchi (ORCID: https://orcid.org/0000-0001-9711-7835)
- Xinyu Chen (ORCID: https://orcid.org/0000-0002-6165-1689)
- Steven P. Rowe (ORCID: https://orcid.org/0000-0003-2897-4694)
- Yusuke Yagi (ORCID: https://orcid.org/0000-0003-0937-3746)
- Konrad Klimek
- Saskia Mühlig
- Hiroyuki Kimura (ORCID: https://orcid.org/0000-0003-4520-734X)
- Constantin Lapa
Institutions
- University of North Carolina at Chapel Hill (US)
- Goethe University Frankfurt (DE)
- Johns Hopkins University (US)
- Okayama University (JP)
- University of Augsburg (DE)
- Environment Agency (GB)
- Johns Hopkins Medicine (US)
- Kyoto College of Medical Science (JP)
- Universitätsklinikum Würzburg (DE)
- University Hospital Frankfurt (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Hypertension
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1161/hypertensionaha.124.24441
- Citations
- 2
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.61