F4H5 Alleviates Increased Outflow Resistance Induced by Emulsified Silicone Oil In Vitro
Emulsified silicone oil leads to blockage of the outflow pathways and an increased IOP in an in vitro human and porcine anterior segment perfusion model. With F4H5, a clinically relevant reversal of this increased outflow resistance was achieved and should be further evaluated.
Authors
- Jonathan Herth
- Philipp Uhl (ORCID: https://orcid.org/0000-0002-8616-5599)
- Maximilian Hammer (ORCID: https://orcid.org/0000-0001-5496-2537)
- Gerd Uwe Auffarth (ORCID: https://orcid.org/0000-0002-6927-5251)
- Sabrina Wohlfart
- Marcel Muuss
- Margarita Karaivanova
- Lea Skrzypczyk
Institutions
- Apple (Israel) (IL)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1167/iovs.66.11.21
- Citations
- 1
- Primary Topic
- Retinal and Macular Surgery
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Joachim Herz Stiftung
- Kowa Company
- Bundesministerium für Bildung und Forschung
- Carl Zeiss Meditec AG
- Santen