Decoding the epigenetic-immune nexus in hepatocellular carcinoma: a Mendelian randomization study reveals BTN3A2, S100A12 and TRIM27 as white blood cell regulators
This study establishes epigenome-immune crosstalk in HCC by identifying BTN3A2, S100A12 and TRIM27 as central methylation-immunoregulatory hubs. The discovered methylation-immune axes provide mechanistic insights for developing combination therapies targeting epigenetic checkpoints to reverse immunosuppressive microenvironments in advanced HCC.
Authors
- Jielu Pan (ORCID: https://orcid.org/0000-0003-2061-394X)
- Nan Shen (ORCID: https://orcid.org/0000-0002-5875-4417)
- Xiao Yu (ORCID: https://orcid.org/0000-0001-7539-3679)
- D. X. Xiao (ORCID: https://orcid.org/0000-0002-8067-5539)
- Yang Qiu (ORCID: https://orcid.org/0000-0002-7600-3684)
- Pei‐min Pu
- Hongyu Miao (ORCID: https://orcid.org/0000-0002-4131-3164)
- Lianjun Xing (ORCID: https://orcid.org/0000-0003-0717-3476)
- Ruiqing Wang (ORCID: https://orcid.org/0009-0000-7431-262X)
- Haiyan Zhang (ORCID: https://orcid.org/0000-0001-7766-2545)
- Zhidong Liu (ORCID: https://orcid.org/0000-0003-1825-6103)
- Lin He (ORCID: https://orcid.org/0000-0003-1079-1195)
- Yanju Zhou (ORCID: https://orcid.org/0009-0006-4782-5589)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1186/s12885-025-14693-w
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61