Identification and Analysis of Mitochondria‐Related Proteins in Haemophilic Arthritis Synovial Membranes Based on Proteomic Analysis
This study identifies molecular pathways and proteins linked to mitochondrial dysfunction in advanced HA, including those involved in the TCA cycle, oxidative phosphorylation and oxidative stress responses. The reduction in NDUFS1 and SOD2 expression may be correlated with mitochondrial dysfunction caused by iron overload in synovial fibroblasts. They provide new insights into the pathogenesis of late-stage HA and offer potential avenues for mitochondria-targeted therapeutic strategies.
Authors
- Li‐Yin Liu (ORCID: https://orcid.org/0000-0002-3831-318X)
- Yongjie Yang (ORCID: https://orcid.org/0000-0003-0318-8224)
- Dasheng Luo (ORCID: https://orcid.org/0000-0003-0486-2428)
- Di Yu (ORCID: https://orcid.org/0000-0002-1176-399X)
- Tao Chen (ORCID: https://orcid.org/0000-0002-6552-3457)
- Jiaxiang Zhang (ORCID: https://orcid.org/0000-0003-0064-604X)
- Haitao Ma
Institutions
- Bengbu Medical College (CN)
- Anhui Medical University (CN)
- Anhui Provincial Hospital (CN)
Publication Details
- Journal
- Haemophilia
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1111/hae.70110
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Anhui Provincial Department of Education