Integrative Proteogenomics and Forward Genetics Reveal a Novel Mitotic Vulnerability in Triple-Negative Breast Cancer
Many TNBCs respond to MTAs, but the underlying cause(s) of this sensitivity remain poorly understood. Herein, we discover that the tumor suppressor PTPN12 regulates mitotic fidelity and MTA sensitivity in a large subset of patients with TNBC, which has significant implications for the use of MTAs in breast cancer.
Authors
- Siddhartha Tyagi (ORCID: https://orcid.org/0000-0001-5543-4787)
- David A. Wheeler (ORCID: https://orcid.org/0000-0002-9056-6299)
- Jarey H. Wang (ORCID: https://orcid.org/0000-0001-9038-4674)
- Pengju Zhang (ORCID: https://orcid.org/0000-0002-6643-0017)
- Hsiang-Ching Chung (ORCID: https://orcid.org/0000-0001-7235-747X)
- Cheyenne Calderon (ORCID: https://orcid.org/0009-0006-1591-6769)
- Shankha Satpathy (ORCID: https://orcid.org/0000-0002-6040-4854)
- Anna Malovannaya (ORCID: https://orcid.org/0000-0003-2953-6485)
- D.R. Mani (ORCID: https://orcid.org/0000-0003-3914-133X)
- Suhas Vasaikar (ORCID: https://orcid.org/0000-0001-9763-3899)
- Sarah J. Kurley (ORCID: https://orcid.org/0000-0002-4127-1443)
- Nathanael S. Gray (ORCID: https://orcid.org/0000-0001-5354-7403)
- Christina Sallas (ORCID: https://orcid.org/0009-0005-2194-0522)
- Nicholas J. Neill (ORCID: https://orcid.org/0000-0003-4205-3488)
- Carolina Gutiérrez (ORCID: https://orcid.org/0000-0002-2941-3461)
- Meenakshi Anurag (ORCID: https://orcid.org/0000-0003-4379-5192)
- Fabio Stossi (ORCID: https://orcid.org/0000-0001-6029-5478)
- C. Kent Osborne (ORCID: https://orcid.org/0000-0002-0044-618X)
- Filip Mundt (ORCID: https://orcid.org/0000-0001-8622-2971)
- Charles Y. Lin (ORCID: https://orcid.org/0000-0002-9155-090X)
- Steven A. Carr (ORCID: https://orcid.org/0000-0002-7203-4299)
- Alaina Lewis (ORCID: https://orcid.org/0009-0009-8760-2293)
- George Miles (ORCID: https://orcid.org/0000-0002-1554-3214)
- Michael T. Lewis (ORCID: https://orcid.org/0000-0002-6330-4007)
- Karsten Krug (ORCID: https://orcid.org/0000-0001-7248-3783)
- Thomas F. Westbrook (ORCID: https://orcid.org/0009-0006-9711-5710)
- Chen Huang (ORCID: https://orcid.org/0000-0003-2777-7365)
- Lacey E. Dobrolecki (ORCID: https://orcid.org/0000-0001-6839-629X)
- Alexander B. Saltzman (ORCID: https://orcid.org/0000-0003-4166-9555)
- Fade Gong (ORCID: https://orcid.org/0009-0001-1964-205X)
- Matthew J. Ellis (ORCID: https://orcid.org/0000-0002-8467-8534)
- Kristen L. Meerbrey (ORCID: https://orcid.org/0009-0007-4522-8091)
- Mei‐Yin C. Polley (ORCID: https://orcid.org/0000-0003-0106-0323)
- Beom-Jun Kim (ORCID: https://orcid.org/0000-0003-3109-8170)
- Charles M. Perou (ORCID: https://orcid.org/0000-0001-9827-2247)
- Michael A. Gillette (ORCID: https://orcid.org/0000-0001-9300-1448)
- Elizabeth A. Bowling (ORCID: https://orcid.org/0000-0002-3370-4632)
- Mayra Orellana (ORCID: https://orcid.org/0009-0001-3596-7030)
- Susan Galloway Hilsenbeck (ORCID: https://orcid.org/0000-0002-7962-673X)
- Tingting Sun (ORCID: https://orcid.org/0009-0003-0638-4105)
- Shayan C. Avanessian (ORCID: https://orcid.org/0000-0002-8883-0070)
- Jitendra K. Meena (ORCID: https://orcid.org/0000-0003-0199-9357)
- Amritha Nair (ORCID: https://orcid.org/0009-0009-1736-2896)
- Doug W. Chan (ORCID: https://orcid.org/0009-0005-8024-4455)
- Bing Zhang (ORCID: https://orcid.org/0000-0001-8676-2425)
- Jin‐Peng Sun (ORCID: https://orcid.org/0000-0003-3572-1580)
- Peng Xiao (ORCID: https://orcid.org/0000-0002-9809-3481)
- Heyuan Li (ORCID: https://orcid.org/0000-0003-4254-4017)
- Duxiao Yang (ORCID: https://orcid.org/0000-0003-3264-8824)
- Martin Weber (ORCID: https://orcid.org/0000-0002-3590-0557)
- Donald J. Reed (ORCID: https://orcid.org/0009-0000-2305-9361)
- Sufeng Mao (ORCID: https://orcid.org/0009-0007-8768-8520)
- Kimberly R. Holloway (ORCID: https://orcid.org/0000-0002-6812-5243)
- Nivetha Ramesh Babu (ORCID: https://orcid.org/0009-0008-4279-2487)
- Maria F. Cardenas
Institutions
- Broad Institute (US)
- University of North Carolina at Chapel Hill (US)
- University of Copenhagen (DK)
- St. Jude Children's Research Hospital (US)
- Johns Hopkins University (US)
- Shandong University (CN)
- Chicago Department of Public Health (US)
- Baylor College of Medicine (US)
- Johns Hopkins Medicine (US)
- University of Jinan (CN)
- University of Chicago (US)
- Friends United (US)
- Cancer Consortium (US)
- Shandong Management University (CN)
- Dana-Farber Cancer Institute (US)
- Kronos Bios (United Kingdom) (GB)
- Children's Cancer Center (US)
- Baylor Genetics (US)
- Massachusetts Institute of Technology (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1158/2159-8290.cd-23-1173
- Citations
- 1
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 1.15