Cognitive impairment and p‐tau217 are high in a vascular patient cohort
Brain health outcomes are rarely evaluated in vascular patients. One hundred sixty-two adults with asymptomatic cardiovascular disease but without diagnoses of cognitive impairment or dementia were evaluated. Phosphorylated tau217 accurately differentiated cognitive impairment in patients with cardiovascular disease. High levels of cognitive impairment and Alzheimer's disease pathology are greatly underdiagnosed in the cardiovascular population.
Authors
- Scott S. Berman (ORCID: https://orcid.org/0000-0001-5236-7646)
- Joseph Sabat (ORCID: https://orcid.org/0000-0002-9671-8783)
- Craig Weinkauf (ORCID: https://orcid.org/0000-0001-9696-5613)
- Edward J. Bedrick (ORCID: https://orcid.org/0000-0002-4215-795X)
- Gene E. Alexander (ORCID: https://orcid.org/0000-0002-6476-5606)
- Luis R. León (ORCID: https://orcid.org/0000-0001-7236-3394)
- Kevin M. Johnson (ORCID: https://orcid.org/0000-0002-8660-0853)
- Joshua Balderman
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Eric M. Reiman (ORCID: https://orcid.org/0000-0002-0705-3696)
- John P. Pacanowski
- Olivia Y. Hung (ORCID: https://orcid.org/0000-0001-5668-2483)
- Federico Yanquez
- Franchell Vazquez
- Haley Wiskoski
- Caronae Howell
- María I. Altbach (ORCID: https://orcid.org/0000-0001-9368-2458)
- Theodore P. Trouard (ORCID: https://orcid.org/0000-0001-9461-2283)
- Raza Mushtaq (ORCID: https://orcid.org/0000-0001-8720-6789)
- Francesca Vitali (ORCID: https://orcid.org/0000-0003-2916-6402)
- Scott French (ORCID: https://orcid.org/0009-0004-1747-949X)
- Fanny M. Elahi (ORCID: https://orcid.org/0000-0003-4663-4992)
- Layla C. Lucas
- Madeline Ally
- Summan Zahra (ORCID: https://orcid.org/0000-0002-9185-3361)
- Nicholas J. Ashton
- Juan Carlos Arias (ORCID: https://orcid.org/0000-0003-4621-9553)
- Cody Kraemer
- Madison Hillis
- Emma Heitkamp
- Cris Escareno
- Gavin Culwell
- Karthik Ainapurapu
Institutions
- Alzheimer's Association (US)
- Allen Institute for Brain Science (US)
- Barrow Neurological Institute (US)
- University of Arizona (US)
- Arizona Science Center (US)
- Pima County Health Department (US)
- Banner - University Medical Center Tucson (US)
- Center for Innovation (US)
- Banner Sun Health Research Institute (US)
- Banner Alzheimer’s Institute
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Gothenburg (SE)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70565
- Citations
- 8
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 11.77
Funders
- Doris Duke Charitable Foundation
- Arizona Alzheimer’s Consortium
- Arizona Biomedical Research Commission
- Health Sciences, University of Arizona
- National Institute on Aging
- National Heart, Lung, and Blood Institute