Activity of Platinum Monotherapy in Patients With Metastatic Castration-Resistant Prostate Cancer and DNA Damage Repair Gene Alterations
Single-agent platinum agents show significant anticancer activity in <i>BRCA</i>-mutated patients with mCRPC without previous PARPi exposure. With their low cost and broad availability, platinum agents offer a practical alternative, particularly in regions where PARPi are inaccessible.
Authors
- Antoine Thiery-Vuillemin (ORCID: https://orcid.org/0000-0001-6822-3401)
- Luigi Cerbone (ORCID: https://orcid.org/0000-0003-0663-244X)
- Karim Fizazi (ORCID: https://orcid.org/0000-0002-6068-9474)
- Kira‐Lee Koster (ORCID: https://orcid.org/0000-0002-6549-8124)
- Silke Gillessen (ORCID: https://orcid.org/0000-0001-5746-6555)
- Florence Joly (ORCID: https://orcid.org/0000-0001-7004-9895)
- Mylène Annonay (ORCID: https://orcid.org/0000-0002-1639-8661)
- François Cherifi (ORCID: https://orcid.org/0000-0003-3842-7168)
- Adrien Rochand
- Casilda Llácer Pérez (ORCID: https://orcid.org/0000-0002-4107-5522)
- Émeline Orillard (ORCID: https://orcid.org/0000-0001-5557-2928)
- Aurelius Omlin (ORCID: https://orcid.org/0000-0002-4783-4788)
- Himisha Beltran (ORCID: https://orcid.org/0000-0003-3259-2226)
- Mihaela D. Aldea (ORCID: https://orcid.org/0000-0001-7685-051X)
- Guilhem Roubaud
- Rafael Morales‐Barrera (ORCID: https://orcid.org/0000-0001-7398-0685)
- Ugo De Giorgi (ORCID: https://orcid.org/0000-0001-7520-2908)
- Alice Bernard‐Tessier (ORCID: https://orcid.org/0000-0001-9706-3945)
- Johann Sebastian De Bono (ORCID: https://orcid.org/0000-0002-2034-595X)
- Elena Castro (ORCID: https://orcid.org/0000-0002-3691-6454)
- Diletta Bianchini (ORCID: https://orcid.org/0009-0002-5071-7301)
- Giulia Baciarello (ORCID: https://orcid.org/0000-0002-5396-5071)
Institutions
- Hebron University (PS)
- Royal Marsden NHS Foundation Trust (GB)
- University of Zurich (CH)
- University of St.Gallen (CH)
- Cornell University (US)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire de Besançon (FR)
- Ente Ospedaliero Cantonale (CH)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- Centre François Baclesse (FR)
- Vall d'Hebron Hospital Universitari (ES)
- Centre Oscar Lambret (FR)
- Institut Bergonié (FR)
- GastroZentrum Hirslanden Zürich (CH)
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- Bicêtre Hospital (FR)
- Instituto de Investigación Biomédica de Málaga (ES)
- Weill Cornell Medicine (US)
- Università della Svizzera italiana (CH)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1200/po-25-00310
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52