Comprehensive Comparison of Somatic, Germline, and Immune Cell Profiles in Upper Tract and Bladder Urothelial Carcinoma
By comprehensive molecular characterization of UC, we observed distinct genomic alterations and tumor microenvironment patterns in UTUC and UCB. Further research is warranted to elucidate the clinical implications of these findings. We compared the genetic and immune features of upper tract and bladder cancers. Our study found key differences that could affect treatment decisions, such as specific gene changes and immune markers. These insights may help doctors personalize therapies and improve patient care.
Authors
- Margaret Meagher (ORCID: https://orcid.org/0000-0003-4512-4106)
- Tyler F. Stewart (ORCID: https://orcid.org/0000-0002-8170-264X)
- Jacob Mercer (ORCID: https://orcid.org/0000-0001-8548-2800)
- Arash Rezazadeh Kalebasty
- Nataliya Mar (ORCID: https://orcid.org/0000-0003-2485-6201)
- Shilpa Gupta (ORCID: https://orcid.org/0000-0002-8775-503X)
- Stamatina Fragkogianni (ORCID: https://orcid.org/0000-0002-5960-8921)
- Petros D. Grivas (ORCID: https://orcid.org/0000-0003-3965-3394)
- Binyam Yilma (ORCID: https://orcid.org/0009-0007-8845-5390)
- Amirali Salmasi (ORCID: https://orcid.org/0000-0002-3884-6322)
- Melissa C. Stoppler
- Rana R. McKay (ORCID: https://orcid.org/0000-0002-0581-7963)
- Aditya Bagrodia (ORCID: https://orcid.org/0000-0002-3358-1193)
Institutions
- Cleveland Clinic (US)
- University of Washington (US)
- University of California, Irvine (US)
- UC San Diego Health System (US)
- Fred Hutch Cancer Center (US)
- Tempus Labs (United States) (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1200/po-25-00289
- Citations
- 1
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01