Effect of Purified Alkaloid (Carpaine) From Water Extract of Carica Papaya L. Leaves on Platelet Count of Carboplatin Induced Thrombocytopenic Sprague Dawley Rats

Current research work is focused on purification of carpaine from water extract of Carica papaya L. leaves, its analyses and its effect on hematology and histopathology of carboplatin induced thrombocytopenic Sprague dawley rats. Functional group detection tests, FTIR and LCMS analyses confirmed the presence of carpaine. Carboplatin induced thrombocytopenic Sprague dawley rats were dozed with purified carpaine (2mg/kg, and 4mg/kg body weight). Positive effect of purified carpaine was observed on platelet count while its effect on other hematological parameters (Hb, RBC, WBC, PCV, MCV, MCHC, MCH, heterophiles, eosinophils, lymphocytes and monocytes) was not note-worthy. Histopathology of kidney, liver, lungs, heart, intestine and spleen revealed no lesions, toxic effects and any abnormality. Thus from the results it can be concluded that carpaine could be the potent biocomponent present in Carica papaya L. leaves responsible for increasing platelet count.