Plasma Exosomal miR-17-5p Regulates Macrophage Polarization by Targeting Bcl11b in Sepsis-Induced Lung Injury
Plasma exosomal miR-17-5p promotes macrophage M1 polarization by targeting Bcl11b and contributes to sepsis-induced lung injury. These findings highlight a previously unrecognized miR-17-5p-Bcl11b regulatory axis and suggest a potential biomarker and therapeutic target for sepsis.
Authors
- Ying Xian (ORCID: https://orcid.org/0000-0001-9993-5540)
- Kouxing Zhang
- Zhongdao Wu (ORCID: https://orcid.org/0000-0001-5879-9757)
- Yinfang Sun
- Lin Lin (ORCID: https://orcid.org/0000-0001-6246-8803)
- Rui Chen (ORCID: https://orcid.org/0000-0002-6488-6133)
- Lifu Wang (ORCID: https://orcid.org/0000-0001-5172-9932)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Kingmed Diagnostics (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/jir.s524742
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81