Toxicities Associated with Systemic Administration of Interleukin-6 in Wistar Albino Rats
We demonstrate that systemic administration of recombinant IL-6 at concentrations ranging between 500-1000ng/kg is well tolerated, above this concentration, dose-dependent toxicities and adverse side effects becoming evident. It would be interesting to explore long-term toxicities associated with the systemic administration of IL-6.
Authors
- Claire M. Mugasa (ORCID: https://orcid.org/0000-0002-7208-7120)
- Enock Matovu (ORCID: https://orcid.org/0000-0003-0714-7032)
- Charles Drago Kato (ORCID: https://orcid.org/0000-0003-3160-6657)
- Kenneth Ssekatawa (ORCID: https://orcid.org/0000-0003-4061-9345)
- Geofrey Ssentamu (ORCID: https://orcid.org/0000-0002-8756-9763)
- Patricia Nabisubi (ORCID: https://orcid.org/0000-0002-1466-695X)
- Monica Namayanja (ORCID: https://orcid.org/0000-0003-4587-3342)
- Vanessa Uwituze
Institutions
- Makerere University (UG)
Publication Details
- Journal
- Journal of Experimental Pharmacology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/jep.s529995
- Primary Topic
- Immunotoxicology and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00