Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding (Adv. Sci. 29/2025)
Joint osteoarthritisEosinophils are crucial in the progression of temporomandibular joint osteoarthritis (TMJOA).In article number 2416030, Jiang Chen and co-workers show OVA/IL-5-induced eosinophils promote synovial Lumican, which binds chondrocyte Anxa1 to inhibit TGF2/Smad2/3 signaling.This reduces cartilage matrix degradation, synovitis, and bone erosion, delaying TMJOA.Eosinophil-stimulated Lumican emerges as a promising therapeutic target for TMJOA treatment.
Authors
- Dexiong Li (ORCID: https://orcid.org/0000-0002-1594-0463)
- Wenxiu Yuan
- Xueshen Qian
- Jiang Chen (ORCID: https://orcid.org/0000-0001-6879-6525)
- Hanyu Lin (ORCID: https://orcid.org/0000-0002-1602-4977)
- Weiping Chen (ORCID: https://orcid.org/0000-0002-0459-0605)
- Wenqian Chen (ORCID: https://orcid.org/0000-0002-2468-1758)
- Yanjing Ou
- Kaixun He (ORCID: https://orcid.org/0000-0003-0183-5600)
- Huachen Chen (ORCID: https://orcid.org/0000-0003-3542-0884)
- Jie Lu (ORCID: https://orcid.org/0009-0006-6993-0080)
- Chengchaozi Wang
- Yuwei Zhou
Publication Details
- Journal
- Advanced Science
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/advs.71023
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00