Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults (Adv. Sci. 29/2025)
A CAsCAde strAtegy for HepAtoCellulAr CArCinomAIn article number 2501420, Yingjie Zeng, Jun Lu, and co-workers present a tumor microenvironment-responsive hybrid nano-prodrug (CA-4S 2 @ES-Cu) that achieves spatiotemporal co-delivery of CA-4 (angiogenesis inhibitor) and ES-Cu (mitochondrial cuproptosis inducer).Synergistic GSH depletion amplifies oxidative stress and DAMPs release, activating immunogenic cell death to transcend monotherapy limitations, thereby establishing a multidimensional therapeutic paradigm for hepatocellular carcinoma.
Authors
- Xian Ge
- Jun Lü (ORCID: https://orcid.org/0000-0003-1625-8682)
- Yuening Cao
- Chaozheng Zhang
- Yingjie Zeng (ORCID: https://orcid.org/0000-0003-3329-946X)
- Defang Li (ORCID: https://orcid.org/0000-0003-4151-9151)
- Tianbao Wang (ORCID: https://orcid.org/0000-0001-9327-0146)
- Yan Wang (ORCID: https://orcid.org/0000-0003-2426-2542)
- Tingting Zhang (ORCID: https://orcid.org/0000-0001-7035-5067)
- Jianan Liu (ORCID: https://orcid.org/0000-0001-5200-8125)
- Xiuli Yang
- Fengjiao Zhou
- Chuantao Zhang (ORCID: https://orcid.org/0000-0001-8122-4855)
- Yao He
- Ke Liu (ORCID: https://orcid.org/0000-0002-2903-8462)
- Senmiao Ren
- Hongyu Chen (ORCID: https://orcid.org/0000-0002-3926-1959)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/advs.71032
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00