Continuous Improvement of Frontal Rhytids Following Glabella Only Treatments With Neuromodulators—A Clinical Prospective Pilot Study
Glabellar-only neuromodulator treatments with 37.5 sU (= 15 IU) effectively reduced forehead rhytid severity, likely by altering the balance between depressor and elevator muscles. This approach minimizes risks associated with direct frontalis injections and offers a novel strategy for forehead rejuvenation. Moreover, the observed progressive improvement across treatment cycles suggests that this strategy may continuously enhance aesthetic outcomes over time, supporting the rationale for maintenance treatments at regular intervals.
Authors
- Victor Ricardo Manuel Muñoz-Lora (ORCID: https://orcid.org/0000-0002-1134-8542)
- Sebastian Cotofana (ORCID: https://orcid.org/0000-0001-7210-6566)
- Michael G. Alfertshofer (ORCID: https://orcid.org/0000-0002-4892-2376)
- Marcelo Germani (ORCID: https://orcid.org/0000-0003-2976-9633)
- Victor Rogerio
- Sachin M. Shridharani (ORCID: https://orcid.org/0000-0002-0193-349X)
- Carlos Martín Bravo (ORCID: https://orcid.org/0009-0000-6366-8428)
- Ana C N Carnevali
- Vanessa Thiesen
- David Eccleston
Institutions
- Queen Mary University of London (GB)
- Universidade de São Paulo (BR)
- Washington University in St. Louis (US)
- Erasmus MC (NL)
- Brazilian Academy of Sciences (BR)
- Business University of Costa Rica (CR)
- Guarulhos University (BR)
- Department of Biological Sciences (RU)
- Instituição Toledo de Ensino (BR)
- IS practice (BE)
- Guangdong Provincial People's Hospital (CN)
- Charité - Universitätsmedizin Berlin (DE)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of Cosmetic Dermatology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/jocd.70188
- Citations
- 2
- Primary Topic
- Botulinum Toxin and Related Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.78