Immunoprotective properties of Scaphium scaphigerum fruits in cyclophosphamide-induced immunosuppressed mice targeting humoral and cell-mediated immunity

Scaphium scaphigerum has been used in Thai traditional medicine for centuries. To validate its traditional use, this study investigated the effects of S. scaphigerum fruits on adaptive immune responses in a cyclophosphamide-induced immunosuppressed mouse model. Administration of S. scaphigerum at 78 mg/kg significantly enhanced delayed-type hypersensitivity reactions and antibody production. These enhanced immune responses were corroborated by increased leukocyte and lymphocyte counts, as well as elevated levels of CD4+ and CD8+ T lymphocytes. Furthermore, notable lymphocyte activation was observed in the germinal centers of the spleen's white pulp. These findings provide initial evidence supporting the immunoprotective potential of S. scaphigerum fruits