To determine the mean NLR(Neutrophil Lymphocyte Ratio) and Mean PLR(Platelet Lymphocyte Ratio) in Covid-19 patients

ABSTRACT Objective: To determine the mean NLR(neutrophil leucocyte ratio) and mean PLR(platelet lymphocyte ratio) in COVID- 19 patients.Study design: Cross Observational Study.Place and Duration of Study: The study was conducted in Medicine unit, Benazir Bhutto Hospital Rawalpindi during the period of May to November 2021. Patients and Methods: A total of 95 patients those who were positive for corona virus by RT-PCR, 20 to 80 years of age, both genders were included. Patients with previous history of asthma, Chronic Obstructive Pulmonary disease, autoimmune disease, ischemic heart disease and chronic liver disease were excluded. The selected patients were given their written informed consent. NLR and PLR were calculated for all the patients on admission versus after 48 hrs. of admission. The data were collected and calculated by the principal researcher on a specially designed proforma. Results: The study included total of 95 patients from 20-80 years with mean age of 46.73 ± 11.16 years. Fifty nine (62.11%) patients were 20-50 years old. Out of total, 39 (41.05%) were male and 56 (58.95%) were females. Mean leucocyte count was 8.05 ± 2.71 x 109/L. Mean leucocyte number was 5465 ± 1231 neutrophils/µL. Mean NLR was 5.15 ± 1.26 and mean PLR was 215.88 ± 38.14 in COVID-19 patients. Mean NLR was not significantly associated with changes over time in COVID-19 patients (p =0.21). Mean PLR was significantly associated with changes over time (p= 0.011), showing a statistically meaningful decrease from admission to 48 hours. Conclusion: The study concluded that mean NLR and mean PLR was associated with COVID-19 patients. PLR decreased significantly, consistent with patient improvement. NLR showed a decreasing trend but not significantly, suggesting it may still reflect immune response but not sharply over 48 hours.