Single‐cell atlas reveals heterogeneous response to FcRn blockade in anti‐AChR antibody‐positive generalised myasthenia gravis
Aberrant B cells and pro-inflammatory T cells contribute critically to generalised myasthenia gravis (gMG) pathogenesis. Neonatal Fc receptor (FcRn) blockade induces immunoglobulin G (IgG) depletion feedback, reflected by increased class-switched BCRs. Th17 cell proliferation is attenuated following FcRn blockade. Antigen processing and presentation pathways are downregulated after FcRn blockade in gMG.
Authors
- Shixiong Huang (ORCID: https://orcid.org/0000-0001-5404-4664)
- Jingjing Liu (ORCID: https://orcid.org/0000-0002-7375-1871)
- Lijie Zhu (ORCID: https://orcid.org/0000-0002-4281-1886)
- Zhirui Liu (ORCID: https://orcid.org/0009-0000-8245-3123)
- Hui‐Ning Li
- Zhigang Cai (ORCID: https://orcid.org/0009-0003-2416-9951)
- Chun‐Sheng Yang (ORCID: https://orcid.org/0000-0003-0846-2851)
- Xiaoyu Huang (ORCID: https://orcid.org/0000-0001-9467-3406)
- Bo Zhang (ORCID: https://orcid.org/0000-0001-8890-8416)
- Chao Zhang (ORCID: https://orcid.org/0000-0002-0659-4597)
- Fu‐Dong Shi (ORCID: https://orcid.org/0000-0002-9675-4637)
Institutions
- Tianjin Medical University General Hospital (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Hainan General Hospital (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
- Tianjin Medical University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/ctm2.70436
- Citations
- 4
- Primary Topic
- Myasthenia Gravis and Thymoma
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City