Multi‐omics profiling identifies <i>TNFRSF18</i> as a novel marker of exhausted CD8⁺ T cells and reveals tumour‐immune dynamics in colorectal cancer
Multi-omics analysis reveals dynamic CD8<sup>+</sup> T cell exhaustion patterns across CRC samples with different TNM stages. TNFRSF18 is highly expressed in exhausted tumour-infiltrating CD8<sup>+</sup> T cells and declines with disease progression. Ribosomal stemness in tumour cells promotes immune evasion by impairing TNF-mediated CD8<sup>+</sup> T cell function.
Authors
- Y B Guo
- Zeyang Zhou (ORCID: https://orcid.org/0000-0003-2296-0742)
- Xiaodong Yang (ORCID: https://orcid.org/0000-0002-4971-2362)
- Hebin Liu (ORCID: https://orcid.org/0000-0003-3690-6018)
- Tengfei Jia
- Xiaojiang Xu (ORCID: https://orcid.org/0000-0001-5758-6581)
- Xin meng Cheng
Institutions
- Tulane University (US)
- Suzhou University of Science and Technology (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/ctm2.70425
- Citations
- 4
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Natural Science Foundation of China