POLE-Mutated Molecular Subtype of Endometrioid Carcinoma: An Aggressive Pilomatrix-Like Neoplasm with Diffusely Aberrant szlig;-Catenin Expression

Endometrioid adenocarcinoma with pilomatrix carcinoma-like morphology represents a recently reported high-grade endometrial carcinoma subtype, frequently harbouring the CTNNB1 gene mutations and demonstrating highly aggressive biological behaviour.However, the present case differs from prior reports by exhibiting a POLE ultra-mutated molecular subtype associated with a favourable prognosis.This study aims to contrast the clinicopathological characteristics of this molecular subtype with conventional cases, elucidate its distinct biological profile, and emphasise the critical correlations between tumour genotype, phenotypic manifestations, and survival outcomes.These findings provide novel insights and evidence to facilitate timely diagnosis and precision therapeutic strategies for this emerging tumour entity.