Identification of Causal Effects of Mitochondrial Dysfunction on the Risk of Multiple Autoimmune Disorders: Multi‐Omics Mendelian Randomization and Colocalization Analyses
These findings provide robust evidence of mitochondrial dysfunction's causal role in AIDs and identify potential pharmacological targets for treatment, offering new insights into precision medicine for AIDs.
Authors
- Guanqun Yao (ORCID: https://orcid.org/0000-0002-6616-9525)
- Xiaopeng Shang (ORCID: https://orcid.org/0000-0002-6500-8762)
- Jingjing Pan
- Shan Jiang (ORCID: https://orcid.org/0000-0002-1540-8506)
- Xin Liao (ORCID: https://orcid.org/0000-0001-8944-7359)
- Zenghao Xu
- Jian Peng (ORCID: https://orcid.org/0000-0002-1243-8857)
- Huaxiang Wu (ORCID: https://orcid.org/0000-0002-5052-7519)
- Jing Luo
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Zhejiang Center for Disease Control and Prevention (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/1756-185x.70383
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China