INFLUENCE OF HEPATITIS C VIRUS POLYMORPHISMS ON HEPATOCELLULAR CARCINOMA EMERGENCE (REVIEW)

R70Q/H, L91M and K10Q/R are most common amino acid substitutions of HCV core protein that are spread within viral population and detected in the cohort of patients with diagnosis of HCC. Analysis of existing data on the topic confirmed relevance of continuing the research of HCV polymorphisms that may induce development of HCC as well as evaluation of their prevalence among people suffering from chronic hepatitis C in order to create a diagnostic test-system based on PCR technology which will allow to establish patients that have an increased risk of HCC.