Vascular adhesion molecule 1+ fibro-adipogenic progenitors mark fatty infiltration in chronic limb-threatening ischemia
Myosteatosis, the pathological accumulation of fat within skeletal muscle, is increasingly recognized as a critical determinant of adverse clinical outcomes in peripheral arterial disease (PAD). Current therapies for PAD focus on revascularization and risk factor modification, but do not directly target myopathy. There is a critical need for regenerative and cellular therapies to restore muscle integrity and function. This study addresses this need by identifying a candidate causal cellular population, Vcam1<sup>+</sup> fibroadipogenic progenitors, and a signaling axis, Nr3c1-Sfrp1, that promote myosteatosis in the ischemic limb.
Authors
- Brianna Garrett
- Kaileen Fei (ORCID: https://orcid.org/0000-0003-1792-2661)
- Yarui Diao (ORCID: https://orcid.org/0000-0001-5842-4082)
- Lindsey A. Olivere (ORCID: https://orcid.org/0000-0002-6626-125X)
- Hana Shafique (ORCID: https://orcid.org/0000-0002-0158-893X)
- Christopher D. Kontos (ORCID: https://orcid.org/0000-0002-8056-3115)
- Camryn Johnson (ORCID: https://orcid.org/0000-0001-8656-1447)
- Changxin Wan (ORCID: https://orcid.org/0000-0001-7345-8221)
- Shaghayegh Sadeghmousavi (ORCID: https://orcid.org/0000-0001-5070-5373)
- James Otto (ORCID: https://orcid.org/0000-0002-4552-1171)
- Kevin W. Southerland (ORCID: https://orcid.org/0000-0002-0306-2130)
- Derek Peters (ORCID: https://orcid.org/0000-0001-6157-0873)
- Qunsheng Dai
- Leo Akers
- Yueyuan Xu (ORCID: https://orcid.org/0000-0002-8571-0700)
- Zhiceng Ji
Institutions
- Duke University (US)
- Trinity College (CA)
- Duke Medical Center (US)
- University of Pittsburgh Medical Center (US)
- Genetic Technologies (Australia) (AU)
Publication Details
- Journal
- JVS Vascular Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jvssci.2025.100295
- Primary Topic
- Peripheral Artery Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00