HCAR2 Exerts Anti-Depressive Effects on Corticosterone-Induced Depression in Mice by Modulating Microglial Activity
Activation of HCAR2 can reduce depressive-like behaviors, neuronal injury, and neuroinflammation. Our findings suggest these neuroprotective effects are, at least in part, mediated through modulation of microglial activity by HCAR2.
Authors
- Yi-Li Yi
- Yong‐Jun Chen (ORCID: https://orcid.org/0000-0002-2076-6295)
- Yangzhi Xie (ORCID: https://orcid.org/0000-0003-2248-9719)
- Jiacheng Chen (ORCID: https://orcid.org/0000-0001-7583-9001)
- Sicong Xu (ORCID: https://orcid.org/0009-0000-0063-4589)
- Jiang Li (ORCID: https://orcid.org/0000-0002-5539-8760)
- Zhao Pan (ORCID: https://orcid.org/0000-0002-4154-6005)
- Ping Zhang
Institutions
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-06-30
- DOI
- https://doi.org/10.31083/fbl39311
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00