Personalised treatment of patients with advanced ovarian cancer: comparative analysis of surgical approaches

The authors analysed the results of treatment of patients with advanced ovarian cancer depending on the surgical approach used and the results of NIRES application. The study was conducted at the University Clinic of Odessa National Medical University. The data of 104 patients with advanced ovarian cancer who underwent laparoscopic surgical access (L-CRS) (54 patients) and patients who underwent laparotomy access (O-CRS) (50 patients) were compared. It was shown that laparoscopic access reduced the incidence of postoperative complications of II–IV degrees according to Clavien-Dindo from 56.4% to 27.8% (χ2=14.56; p < 0.001), the duration of hospitalisation (on average (5.4 ± 1.2) days versus (10.1 ± 2.3) days (t = 14.58; p < 0.001) and the time to the start of adjuvant chemotherapy (4.1 ± 1.2) weeks and (7.2 ± 1.5) weeks, respectively (t = 14.29; p < 0.001) without a significant difference in postoperative mortality. The HIPEC technique has demonstrated its clinical safety in the treatment of peritoneal carcinomatosis of various primary localisations.