Bibliometric and visual analysis of hypertensive nephropathy based on CiteSpace

Objective To conduct a visual analysis of the research status, trends, and hotspots of hypertensive nephropathy. Methods Relevant literature on hypertensive nephropathy from January 2014 to October 21, 2024, was retrieved from the CNKI and the Web of Science core collection databases. The Cite Space 6.3.R1 software was applied for a visual analysis of countries, authors, keywords, etc. Results From 2014 to 2024, studies on hypertensive nephropathy showed that the number of Chinese publications decreased year by year (1,436 articles), while the number of English publications increased slightly (268 articles). The research was mainly concentrated in China, the United States, and Japan. In Chinese research, the core authors were Li Wei, Li Xia, and Li Jing, while in English research, Kohagura Kentaro was a leading author. High-frequency keywords in both Chinese and English centered on drug intervention (valsartan), oxidative stress, and cystatin C diagnosis. In Chinese literature, 10 clusters were formed, with a focus on hemodialysis. In English literature, 8 clusters were identified, with a focus on kidney injury and apoptosis.Conclusion English research delves deeply into the apoptosis mechanism of kidney injury (such as the RAAS-oxidative stress axis), while Chinese research emphasizes the optimization of clinical diagnosis and treatment techniques (multi-marker detection). In the future, attention should be paid to the interaction mechanism between apoptosis and fibrosis, new markers, and the synergistic treatment of traditional Chinese and Western medicine to break through the bottleneck in the prevention and treatment of end-stage renal disease.