Effect of Interactions Between Endothelial Lipase Gene Polymorphisms and Traditional Cardiovascular Risk Factors on Coronary Heart Disease Susceptibility
The <i>rs2000813CT</i> <i>endothelial lipase</i> genotype is potentially associated with an increased CHD risk in females, whereas the <i>CC</i> genotype may confer a protective effect. Integrating <i>endothelial lipase</i> gene variants with traditional cardiovascular risk factors enhances CHD risk prediction in women. Synergistic interaction between <i>endothelial lipase</i> polymorphisms and environmental factors appears to influence CHD occurrence in this population.
Authors
- Juan Yang (ORCID: https://orcid.org/0000-0002-4577-8428)
- Chunhui He (ORCID: https://orcid.org/0000-0002-1068-9986)
- Halisha Airikenjiang
- Dilihumaer Abulaiti
- Jian Zhang (ORCID: https://orcid.org/0000-0002-8825-9097)
- Ting He (ORCID: https://orcid.org/0000-0002-6338-3622)
- Yuhui Zhang (ORCID: https://orcid.org/0000-0002-4373-1845)
- Min Zhu (ORCID: https://orcid.org/0000-0001-9758-4740)
- Qing Tian (ORCID: https://orcid.org/0000-0002-0097-1865)
- Haitang Qiu
- Ying Gao (ORCID: https://orcid.org/0000-0002-9823-6024)
- Xingming Song (ORCID: https://orcid.org/0009-0005-9202-2163)
Institutions
- Xinjiang Medical University (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Beijing Anzhen Hospital (CN)
- Huangshi Central Hospital (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Reviews in Cardiovascular Medicine
- Published
- 2025-07-25
- DOI
- https://doi.org/10.31083/rcm37356
- Citations
- 1
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Natural Science Foundation of Xinjiang