Comparison between GRACE, TIMI and CHA2DS2-VASC scores in predicting severity of coronary artery disease in patients with non ST- Elevation myocardial infarction

Background: TIMI and GRACE risk scores show promise as coronary artery disease (CAD) prognostic markers. Using the SYNTAX score as a benchmark, this study aimed to determine if clinical risk scores were associated with the angiographic severity and extent of coronary artery disease (CAD) in a group of Egyptian persons. A secondary objective of the study was to ascertain if the GRACE, TIMI, and CHA2DS2-VASc scores could be helpful in predicting the outcomes of angiography in hospitalized patients with NSTEMI. Methods: This observational, cross-sectional study was carried out on 146 patients with a diagnosis of NSTEMI admitted to Wadi El Neel Hospital. All patients were subjected to full history taken including [personal history, past history and drug history], biochemical tests and electrocardiography and echocardiography. Results: patients with a CHA2DS2-vasc score > 2 have a four-fold to have “high” SYNTAX score. Patients with a GRACE score > 121 have a four-fold to have “high” SYNTAX score. Patients with a TIMI score > 4 have a five-fold to have “high” SYNTAX score. A CHA2DS2-vasc score > 2 in a patient with NSTEMI is an independent predictor of “high” SYNTAX score. A GRACE score > 121 in a patient with NSTEMI is an independent predictor of “high” SYNTAX score. Conclusions: Along with correlating with the SYNTAX score-measured amount of coronary disease, GRACE, TIMI, and CHA2DS2-VASc scores can also foretell a more complex case of coronary artery disease (defined as a SYNTAX score of 22 or higher).