Adenovirus Nanoparticles Displaying RBD Induce a Protective Immune Response Against BA.5 in Mice
We developed a universal nanoparticle vaccine platform and obtained a trivalent vaccine candidate rAd3/7-SpyRBD, against SARS-CoV-2, Ad3, and Ad7, and this is the first time to use SpyCatcher/SpyTag technology in a bivalent rAd3/7 vector for trivalent immunity.
Authors
- Chengxing Zhou
- Zhongfang Wang (ORCID: https://orcid.org/0000-0003-3236-5170)
- Sihao Deng (ORCID: https://orcid.org/0000-0002-5142-3519)
- Xingui Tian (ORCID: https://orcid.org/0000-0001-9761-6677)
- Jinwei Yuan (ORCID: https://orcid.org/0000-0002-4226-1853)
- Shuai Yuan (ORCID: https://orcid.org/0000-0001-6718-2994)
- Rong Zhou (ORCID: https://orcid.org/0000-0001-7322-3561)
- Donglan Liu (ORCID: https://orcid.org/0000-0002-8342-7637)
- Xiaoyun Yang (ORCID: https://orcid.org/0000-0002-1374-2201)
- Wenkuan Liu (ORCID: https://orcid.org/0000-0003-3020-9158)
- Hang Liu (ORCID: https://orcid.org/0000-0002-1379-6314)
- Xiao Li (ORCID: https://orcid.org/0000-0001-7866-3160)
- Qiong Zhang (ORCID: https://orcid.org/0000-0001-5001-8434)
- Yuhui Zhu (ORCID: https://orcid.org/0000-0002-9826-2054)
- Duo Xu (ORCID: https://orcid.org/0000-0002-6385-3671)
- Yujie Yang (ORCID: https://orcid.org/0000-0002-9610-8221)
- Lihua Ye (ORCID: https://orcid.org/0000-0001-7000-2341)
- Xiaohong Liao
- Chuncong Mo
- Zhihui Lai
- D. J. Huang
Institutions
- Key Laboratory of Guangdong Province (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangdong Inspection and Quarantine Technology Center (China) (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/ijn.s511173
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Medical University
- National Natural Science Foundation of China