Medical Hemorrhoid Gel Ameliorates Croton Oil-Induced Hemorrhoids by Suppressing the NLRP3 Inflammasome Activation via NF-κB Signaling Pathway
Our study substantiated that MHG exerts anti-hemorrhoidal effects through NLRP3 inflammasome suppression via NF-κB pathway regulation. This mechanistic insight provides scientific validation for clinical application of MHG in HD management.
Authors
- Jingjing Cai (ORCID: https://orcid.org/0000-0003-0708-3809)
- Zhiyong Ai (ORCID: https://orcid.org/0000-0001-6247-5149)
- Wei Liu (ORCID: https://orcid.org/0000-0001-6565-5815)
- Yun Li (ORCID: https://orcid.org/0000-0002-0798-1070)
- Dalee Zhou (ORCID: https://orcid.org/0000-0001-7806-0589)
- D Yuan (ORCID: https://orcid.org/0009-0006-0623-8628)
Institutions
- Hubei University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/jir.s526589
- Primary Topic
- Anorectal Disease Treatments and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00