Accelerating cross-modality reaction optimization <i>via</i> robotically automated vacuum enabled direct-inject mass spectrometry (RAVE MS)
RAVE MS utilizes low cost mass spectrometer and autosampler hardware to continuously inject samples for analysis at a sampling rate of approximately 12 s per sample with comparable results to commercial direct inject systems.
Authors
- Sarah R. Moor (ORCID: https://orcid.org/0000-0001-5579-407X)
- Elliot J. Medcalf
- Shane T. Grosser (ORCID: https://orcid.org/0000-0002-9268-7545)
- Noah P. Dunham (ORCID: https://orcid.org/0000-0001-8006-9566)
- Claire M. Eberle
- Hang Hu (ORCID: https://orcid.org/0000-0002-8590-9787)
- Maximilian Gantz (ORCID: https://orcid.org/0000-0003-0061-9308)
- Daniel Holland-Moritz (ORCID: https://orcid.org/0000-0003-4634-6122)
- Joseph B. Parry (ORCID: https://orcid.org/0000-0001-5979-6814)
- Andrew C. Strakham
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- University of Cambridge (GB)
Publication Details
- Journal
- Reaction Chemistry & Engineering
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5re00248f
- Citations
- 1
- Primary Topic
- Analytical Chemistry and Chromatography
- Type
- article
- Field-Weighted Citation Impact
- 0.76