Molecular subtypes and clinicopathological characteristics of breast cancer across age groups: a retrospective analysis

Aims: To evaluate the relationship between age at diagnosis and molecular subtypes of breast cancer in a retrospective single-center cohort at the Ordu University Training and Research Hospital. Methods: We reviewed the data of 139 female patients diagnosed with invasive breast carcinoma between January 2020 and March 2025. Clinical and pathological data, including age at diagnosis, body-mass index (BMI), TNM stage, histological subtype and grade, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) status, and Ki-67 index, were extracted from the medical records. Tumors were classified into luminal A, luminal B, HER2-enriched, and triple-negative subtypes. Patients were stratified into three age groups: