Conjugated Polymer Nanoparticles for Multifunctional Bioelectronics and Sensing P3ht:Pcbm-Nps Embedded in Peo Hydrogel

Multifunctional bioelectronic systems are crucial for next-generation medical applications, enabling real-time sensing, targeted stimulation, and effective biological integration. In this work, we present a novel approach integrating conjugated polymer (CP) nanoparticles (NPs), made of poly(3-hexylthiophene, (P3HT) blended with [6], [6] phenyl-C61-butyric acid methyl ester (PCBM), into polyethylene oxide (PEO) hydrogels to develop a bioelectronic interface for biophotonic applications. We demonstrate that this composite material exhibits adequate electrochemical performance, providing, a photo-induced stable and reproducible photocurrent response (current density ranging from 13 to <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$25 \text{nA} / \text{cm}^{2}$</tex>). This work enhances CPNPs potential for bio-sensing/stimulation applications and introduces PEO|P3HT:PCBM-NPs composites as promising candidates for applications in neural interfacing, photo-biosensing, and regenerative medicine.