Exploring the impact of macrophage polarization and Modic changes on baseline clinical condition in radiculopathy due to lumbar disc herniation
The link between back and leg pain and intervertebral disc inflammation appears to be influenced by the presence or absence of MC. These findings reveal distinct roles for M1 and M2 macrophages in clinical symptoms, warranting further investigation. Large-scale cohort studies are needed to validate and expand upon these observations.
Authors
- Wensen Li (ORCID: https://orcid.org/0000-0002-6261-2278)
- Carmen Vleggeert‐Lankamp (ORCID: https://orcid.org/0000-0001-9597-7225)
- Niek Djuric (ORCID: https://orcid.org/0000-0002-5556-6955)
- Christiaan Mink
Institutions
- Erasmus MC (NL)
- Medisch Centrum Haaglanden (NL)
- Spaarne Ziekenhuis (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Brain and Spine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.bas.2025.104388
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00