Genetic Evidence for Causal Relationships Between Circulating Cathepsin Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Study
To our knowledge, this is the first MR study to systematically evaluate the causal role of cathepsins in COPD. Further research, particularly clinical trials, is warranted to validate these associations and explore the therapeutic potential of targeting cathepsins in COPD management.
Authors
- Suyan Tian (ORCID: https://orcid.org/0000-0002-5942-1542)
- Chao Duan (ORCID: https://orcid.org/0000-0003-4423-2156)
- Ao Zhang (ORCID: https://orcid.org/0009-0009-6332-9915)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation
- Published
- 2025-01-01
- DOI
- https://doi.org/10.15326/jcopdf.2025.0626
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- People's Government of Jilin Province