Rechallenge of 5-Fluorouracil in a Patient With Coronary Vasospasm Unable to Receive Oral Medications
This case highlights the challenge of 5-FU rechallenge in patients unable to take oral prophylaxis. Transdermal nitroglycerin monotherapy proved insufficient, suggesting that intravenous prophylaxis may be required. Future studies should determine optimal strategies for preventing CV in patients with a similar presentation.
Authors
- Peter D. Whooley
- Samantha Rizzo (ORCID: https://orcid.org/0000-0003-2759-8287)
- Christopher W. Hoeger (ORCID: https://orcid.org/0000-0002-9008-1099)
- Mauro Rogério de Barros Wanderley (ORCID: https://orcid.org/0000-0001-6502-5602)
- James D. Chang (ORCID: https://orcid.org/0000-0003-3211-3299)
- Aarti H. Asnani (ORCID: https://orcid.org/0000-0003-4967-9918)
- Jenica N. Upshaw
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
Publication Details
- Journal
- JACC Case Reports
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jaccas.2025.104550
- Citations
- 1
- Primary Topic
- Chemotherapy-related skin toxicity
- Type
- article
- Field-Weighted Citation Impact
- 2.00